Section: Partnerships and Cooperations

Regional Initiatives

DIGITEO and Cancéropôle IdF

The DIGITEO IdF LSC ALMA program, coordinated by C. Bonnet (DISCO team, INRIA Saclay IdF) studies a model of leukaemia based on previous works by M. Adimy and F. Crauste (Lyon), with theoretical model design adjustments and analysis in J. L. Avila Alonso's Ph D thesis (supervised by C. Bonnet, S. Niculescu and J. Clairambault) and experimental parameter identification initiated by F. Merhi, postdoc of Bang (Dec. 2010-Nov. 2011), working at St. Antoine Hospital (Paris), under the supervision of J. Clairambault and C. Bonnet to link experimental and theoretical aspects and of J.-P. Marie and R. Tang (INSERM-UPMC) to supervise biological experiments on leukaemic cells. ALMA has been granted for 3 years, beginning in December 2010.

More recently, the Cancéropôle IdF ALMA2 program has taken over the experimental identification part in St. Antoine Hospital, together with further model design in Bang - and Disco with the continuation of J.L. Avila's PhD thesis -, for 18 months (Oct. 2011-March 2013) with the postdoc of A. Ballesta, shared between J.-P. Marie's team and Bang. With this postdoc project will also be developed the theoretical and experimental - in leukaemic cell cultures - study of combined therapies by classical cytotoxics (anthracyclins, aracytin) and recently available targeted therapies (anti-Flt-3). A possible emergence of drug resistance to these drugs is also a question that will be studied both theoretically and experimentally in leukaemic cell cultures, in relation with the interdisciplinary French consortium DarEvCan (cf. supra “Optimisation of cancer chemotherapy”) in which both Bang and J.-P. Marie's team participate.

INRA.

Collaboration with INRA (Isabelle Hue, Juhui Wang, Alain Trubuil) on Trophoblast development. One PhD student position in Bang (Chadha Chettaoui) is funded within the Doctoral School Ecole du Vivant, Paris.